DETAILED NOTES ON LAUGHING GAS

The last proposed mechanism of RBC vasodilation during the presence of nitrite could be the reduction of nitrite to NO by Hb. Brooks initial examined the nitrite Hb conversation in 1937 and this get the job done was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks,